Лаборатория трансляционной биопсихиатрии

Заведующая лабораторией
главный научный сотрудник, доктор биологических наук, доцент
Амстиславская Тамара Геннадьевна 
электронная почта: This email address is being protected from spambots. You need JavaScript enabled to view it.
телефон: (383) 373-01-85

 

Сотрудники

  ФИО Должность, ученая степень, ученое звание Телефон Адрес электронной почты
1 Амстиславская Тамара Геннадьевна
Заведующий лабораторией,
Главный научный сотрудник

доктор биологических наук
(383) 373-01-85 This email address is being protected from spambots. You need JavaScript enabled to view it.
2 Калуев Алан Валерьевич Ведущий научный сотрудник (383) 373-01-85 This email address is being protected from spambots. You need JavaScript enabled to view it.
3 Черезис Сергей Владимирович Старший научный сотрудник 
кандидат биологических наук
(383) 373-01-85 This email address is being protected from spambots. You need JavaScript enabled to view it.
4 Глазачева Валентина Юрьевна Младший научный сотрудник (383) 373-01-85 This email address is being protected from spambots. You need JavaScript enabled to view it.
5 Смирнова Кристина Вячеславовна Лаборант (383) 373-01-85  

 

Основные направления исследований

Изучение нейробиологических и молекулярно-клеточных механизмов когнитивных и эмоциональных нарушений, а также нейродегенеративных процессов на экспериментальных моделях патогенеза центральной нервной системы у зебраданио (Danio rerio).

Избранные публикации

2018

  • de  Abreu M. S., Friend A. J., Amstislavskaya T. G., Kalueff A. V. Commentary: Establishing zebrafish as a model to study the anxiolytic effects of scopolamine // Frontiers in Pharmacology. – 2018. – Vol. 9. - P.293 (doi: 10.3389/fphar.2018.00293). https://www.frontiersin.org/articles/10.3389/fphar.2018.00293/full
  • Zabegalov K. N., Kolesnikova T. O., Khatsko S. L., Volgin A. D., Yakovlev O. A., Amstislavskaya T. G., Alekseeva P. A., Meshalkina D. A., Friend A. J., Bao W., Demin K. A., Gainetdinov R. R., Kalueff A. V. Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models // European Journal of Pharmacology. – 2018. – Vol. 829. – P. 129-140 (doi: 10.1016/j.ejphar.2018.04.003). https://www.ncbi.nlm.nih.gov/pubmed/29627310
  • Mezzomo N. J., Fontana B. D., Kalueff A. V., Barcellos L. J. G., Rosemberg D. B. Understanding taurine CNS activity using alternative zebrafish models // Neuroscience and Biobehavioral Reviews. – 2018. – Vol. 90 – P. 471-485 (doi: 10.1016/j.neubiorev.2018.04.012).
  • Lakstygal A. M., de Abreu M. S., Kalueff A. V. Zebrafish models of epigenetic regulation of CNS functions // Brain Research Bulletin. – 2018. – Vol. 142. – P.:344-351 (doi: 10.1016/j.brainresbull.2018.08.022).
  • Volgin A. D., Yakovlev O. V., Demin K. A., Abreu M. S., Rosemberg D. B., Meshalkina D. A., Alekseeva P. A., Friend A. J., Amstislavskaya T. G., Kalueff A. V. Understanding the role of environmental enrichment in zebrafish neurobehavioral models // Zebrafish. – 2018. – Vol. 15, № 5. – P. 425-432 (https://doi.org/10.1089/zeb.2018.1592).
  • de Abreu M. S., Friend A. J., Demin K. A., Amstislavskaya T. G., Bao W., Kalueff A. V. Zebrafish models: do we have valid paradigms for depression? // Journal of Pharmacolological and Toxicological Methods. – 2018. – Vol. 94, Pt.2. – P. 16-22 (https://doi.org/10.1016/j.vascn.2018.07.002).

2017

  • Ragaeva DS, Tikhonova MA, Petrova OM, Igonina TN, Rozkova IN, Brusentsev EY, Amstislavskaya TG, Amstislavsky SY. Neonatal reflexes and behavior in hypertensive rats of ISIAH strain. Physiol Behav. 2017 Jun 1;175:22-30. doi: 10.1016/j.physbeh.2017.03.026
  • Tikhonova MA, Ho SC, Akopyan AA, Kolosova NG, Weng JC, Meng WY, Lin CL, Amstislavskaya TG, Ho YJ. Neuroprotective Effects of Ceftriaxone Treatment on Cognitive and Neuronal Deficits in a Rat Model of Accelerated Senescence. Behav Brain Res. 2017 May 6;330:8-16. doi: 10.1016/j.bbr.2017.05.002
  • Ranneva SV, Pavlov KS, Gromova AV, Amstislavskaya TG, Lipina TV. Features of emotional and social behavioral phenotypes of calsyntenin2 knockout mice. Behav Brain Res. 2017 Aug 14; 332:343-354. doi: 10.1016/j.bbr.2017.06.029
  • Wu YJ, Hsu MT, Ng MC, Amstislavskaya TG, Tikhonova MA, Yang YL, Lu KT. Fragile X Mental Retardation-1 Knockout Zebrafish Shows Precocious Development in Social Behavior. Zebrafish. 2017 Oct;14(5):438-443. doi: 10.1089/zeb.2017.1446
  • Wu YJ, Chen YL, Tang TH, Ng MC, Amstislavskaya TG, Tikhonova MA, Yang YL, Lu KT. Unilateral stimulation of the lateral division of the dorsal telencephalon induces synaptic plasticity in the bilateral medial division of zebrafish. Sci Rep. 2017 Aug 22;7(1):9096. doi: 10.1038/s41598-017-08093-9

2016

  • Wu HF, Amstislavskaya TG, Chen PH, Wu TF, Chen YH, Jen CP. Preconcentration-enhanced Immunosensing for Whole Human Cancer Cell Lysate based on a Nanofluidic Preconcentrator. BioChip J. 2016, 10(3): 159-166 DOI 10.1007/s13206-016-0203-y
  • Weng JC, Tikhonova MA, Chen JH, Shen MS, Meng WY, Chang YT, Chen KH, Liang KC, Hung CS, Amstislavskaya TG, Ho YJ. Ceftriaxone prevents the neurodegeneration and decreased neurogenesis seen in a Parkinson's disease rat model: An immunohistochemical and MRI study. Behav Brain Res. 2016, 305:126-139. doi: 10.1016/j.bbr.2016.02.034
  • Chen YH, Wu HF, Amstislavskaya TG, Li CY, Jen CP. A simple electrokinetic protein preconcentrator utilizing nano-interstices. Biomicrofluidics 10, 024121 (2016); doi: 10.1063/1.4946768 View online: http://dx.doi.org/10.1063/1.4946768

2015

  • Lu KT, Huang TC, Wang JY, You YS, Chou JL, Chan MW, Wo PY, Amstislavskaya TG, Tikhonova MA, Yang YL. NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1α expression. Pflugers Arch, (Pflügers Archiv: European Journal of Physiology), 2015 Aug;467(8):1651-61. doi: 10.1007/s00424-014-1588-x. 
  • Jen CP, Amstislavskaya TG, Chen KF, Chen YH. Sample preconcentration utilizing nanofractures generated by junction gap breakdown assisted by self-assembled monolayer of gold nanoparticles. PLoS One. 2015 May 13;10(5):e0126641. doi: 10.1371/journal.pone.0126641. eCollection 2015.
  • Tikhonova MA, Romaschenko AV, Akulov AE, Ho YJ, Kolosova NG, Moshkin MP, Amstislavskaya TG. Comparative study of perception and processing of socially or sexually significant odor information in male rats with normal or accelerated senescence using fMRI. Behav Brain Res. 2015, V. 294, P. 89–94. doi: 10.1016/j.bbr.2015.08.001
  • Huang CK, YT Chang, TG Amstislavskaya, MA Tikhonova, CL Lin, CS Hung, TJ Lai, YJ Ho. Synergistic effects of ceftriaxone and erythropoietin on neuronal and behavioral deficits in an MPTP-induced animal model of Parkinson’s disease dementia. Behav Brain Res. 2015, V.294, P.198-207
  • Tikhonova M.A., Amstislavskaya T.G. Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation. Russian Journal of Genetics: Applied Research, 2016, V6, N4, P410-416. doi: 10.1134/S2079059716040201. http://link.springer.com/article/10.1134/S2079059716040201?view=classic

2014

  • Hung YT, Tikhonova MA, Ding SJ, Kao PF, Lan HH, Liao JM, Chen JH, Amstislavskaya TG, Ho YJ. Effects of chronic treatment with diosgenin on bone loss in a D-galactose-induced aging rat model. The Chinese Journal of Physiology, 2014, V. 57(3), P.121-127. doi: 10.4077/CJP.2014.BAC199. 
  • Tikhonova MA, Yu CH, Kolosova NG, Gerlinskaya LA, Maslennikova SO, Yudina AV, Amstislavskaya TG, Ho YJ. Comparison of behavioral and biochemical deficits in rats with hereditary defined or D-galactose-induced accelerated senescence: evaluating the protective effects of diosgenin. Pharmacology, Biochemistry and Behavior, 2014, V.120, P.7-16
  • Ho SC, Hsu CC, Yu CH, Huang WN, Tikhonova MA, Ho MC, Wu FY, Amstislavskaya TG, Ho YJ. Measuring attention in a Parkinson's disease rat model using the 5-arm maze test. Physiol Behav. 2014, V.130 C.176-181
  • Ho SC, Hsu CC, Pawlak CR, Tikhonova MA, Lai TJ, Amstislavskaya TG, Ho YJ. Effects of ceftriaxone on the behavioral and neuronal changes in an MPTP-induced Parkinson's disease rat model. Behav Brain Research, 2014, 268 C.177-184
  • Jen CP, Amstislavskaya TG, Kuo CC, Chen YH. Protein preconcentration using nanofractures generated by nanoparticle-assisted electric breakdown at junction gaps. PLoS One. 2014 Jul 15;9(7):e102050. doi: 10.1371/journal.pone.0102050. eCollection 2014
  • Ko MC, Lee MC, Amstislavskaya TG, Tikhonova MA, Yang YL, Lu KT. Inhibition of NKCC1 Attenuated Hippocampal LTP Formation and Inhibitory Avoidance in Rat. PLoS One. 2014 Nov 4;9(11):e106692. doi: 10.1371/journal.pone.0106692. eCollection 2014

Основное оборудование

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Наименование оборудования Фирма-производитель Страна происхождения
1 Спектрофлуориметр F-5301PC в комплекте с компьютеро Shimadzu Япония
Программно-аппаратный комплекс для оценки экспрессии генов и генотипирования (на основе анализатора LightCycler 480-II (Roche) для проведения ПЦР-анализа) Roche   Швейцария
3 4-канальный автоматический рт-ПЦР амплификатор Eco Real-Time PCR (Illumina) Illumina Сингапур
4 Спектрофотометр NanoDrop 2000 Thermo Scientific США
5 Микроскоп  медико-биологический Nikon Eclipse Ci Nikon Китай
6 Микротом-Криостат Cryo3-базовая модель с принадлежностями Histosafe Китай
7 Фотометр для микропланшетов Bio Rad Япония
8 Система для изучения поведения рыб в стандартных лабораторных тестах Noldus (The Novel Tank Diving Test, T-Maze for Zebrafish Apparatus) Noldus Нидерланды